早老素
早老素(英語:,又译为早老蛋白)是一族相關聯的多跨膜蛋白充當了一部分的γ-分泌酶(作為催化劑[2])膜內蛋白酶複合物。
| Presenilin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
![]() Solution structure of the human presenilin-1 CTF subunit.[1] | |||||||||
| 鑑定 | |||||||||
| 標誌 | Presenilin | ||||||||
| Pfam | PF01080(旧版) | ||||||||
| Pfam宗系 | CL0130(旧版) | ||||||||
| InterPro | IPR001108 | ||||||||
| MEROPS | A22 | ||||||||
| TCDB | 1.A.54 | ||||||||
| OPM家族 | 277 | ||||||||
| OPM蛋白 | 4hyg | ||||||||
| |||||||||
| presenilin 1 (Alzheimer's disease 3) | |
|---|---|
| 識別 | |
| 符號 | PSEN1 |
| 替換符號 | AD3 |
| Entrez | 5663 |
| HUGO | 9508 |
| OMIM | 104311 |
| RefSeq | NM_000021 |
| UniProt | P49768 |
| 其他資料 | |
| EC編號 | 3.4.23.- |
| 基因座 | 14 q24.3 |
| presenilin 2 (Alzheimer's disease 4) | |
|---|---|
| 識別 | |
| 符號 | PSEN2 |
| 替換符號 | AD4 |
| Entrez | 5664 |
| HUGO | 9509 |
| OMIM | 600759 |
| RefSeq | NM_000447 |
| UniProt | P49810 |
| 其他資料 | |
| EC編號 | 3.4.23.- |
| 基因座 | 1 q31-q42 |
参考文献
- PDB 2KR6; Doetsch V. . To be published. 2010. doi:10.2210/pdb2kr6/pdb.
- Li, Xiaochun; Dang, Shangyu; Yan, Chuangye; Gong, Xinqi; Wang, Jiawei; Shi, Yigong. . Nature. 2013-01-03, (493): 56 [2014-07-27]. doi:10.1038/nature11801. (原始内容存档于2014-08-09) (中文(简体)).
外部链接
| 维基词典中的词条「」。 |
- The MEROPS online database for peptidases and their inhibitors: Presenilin 1 A22.001 (页面存档备份,存于), Presenilin 2 A22.002
- Dominantly Inherited Alzheimer Network (DIAN) (页面存档备份,存于)
- Dominantly Inherited Alzheimer Network (DIAN) Expanded Registry (页面存档备份,存于)
- 醫學主題詞表(MeSH):Presenilins
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