5-HT_2B受體

5-HT2B受體
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4NC3、4IB4
識別號
别名	HTR2B；, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B
外部ID	OMIM：601122 MGI：109323 HomoloGene：55492 GeneCards：HTR2B
為以下藥物的標靶
	LSD、5-carboxamidotryptamine、血清素、8-OH-DPAT、AL-37350A、α-methyl-5-HT、布苯丙胺、BW-723C86、過乳降、CGS-12066A、2,5-二甲氧基-4-碘代苯丙胺、洛卡色林、MK-212、norfenfluramine、Org 12962、ORG-37684、培高利特、吲哚洛尔、quinpirole、喹哌嗪、ru-24969、N-(3-三氟甲基苯基)哌嗪、色胺、VER-3323、brl-15572、邁克寧（又譯麥角胺）、gr-127935、间氯苯基哌嗪、甲基麦角新碱、美西麦角、sb-216641、1-naphthylpiperazine、阿戈美拉汀、阿樸嗎啡、溴隱亭、氯氮平、氟西汀、glemanserin、氟哌啶醇、酮色林、L-741,626、麥角乙脲、褪黑素、mesulergine、甲麦角林、metitepine、米塞林、seproxetine、哌波色罗、吡貝地爾、蘿芙木、ritanserin、roxindole、RS-102221、RS-127445、sarpogrelate、SB 204741、sb-206553、SB 242084、SB 243213、SB-277,011-A、SDZ SER-082、spiperone、spiramide、spiroxatrine、特麦角脲、曲唑酮、volinanserin、呫诺美林、育亨宾、齐美定[1]
基因位置（人类）
染色体	2號染色體[2]
终止	231,125,042 bp[2]
基因位置（小鼠）
染色体	小鼠1号染色体[3]
终止	86,039,692 bp[3]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• G protein-coupled receptor activity; • GTPase activator activity; • signal transducer activity; • G protein-coupled serotonin receptor activity; • G-protein alpha-subunit binding; • serotonin binding; • neurotransmitter receptor activity;
細胞組分	• 細胞質; • integral component of membrane; • 膜; • 细胞膜; • 突触; • 细胞连接; • neuron projection; • integral component of plasma membrane; • 核质; • 树突;
生物學過程	• intestine smooth muscle contraction; • smooth muscle contraction; • G protein-coupled receptor internalization; • release of sequestered calcium ion into cytosol; • regulation of behavior; • positive regulation of endothelial cell proliferation; • positive regulation of MAP kinase activity; • 磷酸化; • positive regulation of cytokine production; • 血管收縮; • ERK1 and ERK2 cascade; • positive regulation of phosphatidylinositol biosynthetic process; • cardiac muscle hypertrophy; • heart morphogenesis; • cellular calcium ion homeostasis; • neural crest cell differentiation; • negative regulation of apoptotic process; • negative regulation of cell death; • activation of phospholipase C activity; • protein kinase C signaling; • cGMP biosynthetic process; • cellular response to temperature stimulus; • positive regulation of GTPase activity; • 心脏发育; • positive regulation of nitric-oxide synthase activity; • protein kinase C-activating G protein-coupled receptor signaling pathway; • embryonic morphogenesis; • serotonin receptor signaling pathway; • neural crest cell migration; • positive regulation of cell population proliferation; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • phosphatidylinositol 3-kinase signaling; • negative regulation of autophagy; • positive regulation of cell division; • calcium-mediated signaling; • 訊息傳遞; • phospholipase C-activating G protein-coupled receptor signaling pathway; • G protein-coupled serotonin receptor signaling pathway; • G protein-coupled receptor signaling pathway; • 动物行为; • cGMP-mediated signaling; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • 化学性突触传递;
	Sources:Amigo / QuickGO
直系同源
	3357
	15559
	ENSG00000135914
	ENSMUSG00000026228
	P41595
	Q02152
	NM_000867; NM_001320758
	NM_008311
	NP_000858; NP_001307687
	NP_032337
	維基數據

5-羥色胺受體2B或血清素受體2B (英語:5-Hydroxytryptamine receptor 2B (5-HT_2B)或serotonin receptor 2B) 是在人類中由HTR2B基因編碼的蛋白質[6][7]。 5-HT_2B是5-HT2受體家族中的成員。

参见

5-羟色胺受体

参考资料

.
GRCh38: Ensembl release 89: ENSG00000135914 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026228 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. （原始内容存档于2019-09-18）.
Schmuck K, Ullmer C, Engels P, Lübbert H. . FEBS Letters. Mar 1994, 342 (1): 85–90 [2017-01-24]. PMID 8143856. doi:10.1016/0014-5793(94)80590-3. （原始内容存档于2019-02-15）.

深入閱讀

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Kursar JD, Nelson DL, Wainscott DB, Baez M. . Molecular Pharmacology. Aug 1994, 46 (2): 227–34. PMID 8078486.
Schmuck K, Ullmer C, Engels P, Lübbert H. . FEBS Letters. Mar 1994, 342 (1): 85–90. PMID 8143856. doi:10.1016/0014-5793(94)80590-3.
Launay JM, Birraux G, Bondoux D, Callebert J, Choi DS, Loric S, Maroteaux L. . The Journal of Biological Chemistry. Feb 1996, 271 (6): 3141–7. PMID 8621713. doi:10.1074/jbc.271.6.3141.
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Kim SJ, Veenstra-VanderWeele J, Hanna GL, Gonen D, Leventhal BL, Cook EH. . Molecular and Cellular Probes. Feb 2000, 14 (1): 47–52. PMID 10722792. doi:10.1006/mcpr.1999.0281.
Manivet P, Mouillet-Richard S, Callebert J, Nebigil CG, Maroteaux L, Hosoda S, Kellermann O, Launay JM. . The Journal of Biological Chemistry. Mar 2000, 275 (13): 9324–31. PMID 10734074. doi:10.1074/jbc.275.13.9324.
Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C. . The Journal of Biological Chemistry. Apr 2001, 276 (16): 12974–82. PMID 11150294. doi:10.1074/jbc.M008089200.
Manivet P, Schneider B, Smith JC, Choi DS, Maroteaux L, Kellermann O, Launay JM. . The Journal of Biological Chemistry. May 2002, 277 (19): 17170–8. PMID 11859080. doi:10.1074/jbc.M200195200.
Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS. . British Journal of Pharmacology. Mar 2002, 135 (5): 1144–51. PMC 1573235 . PMID 11877320. doi:10.1038/sj.bjp.0704571.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S. . Oncogene. May 2003, 22 (21): 3307–18. PMID 12761501. doi:10.1038/sj.onc.1206406.
Slominski A, Pisarchik A, Zbytek B, Tobin DJ, Kauser S, Wortsman J. . Journal of Cellular Physiology. Jul 2003, 196 (1): 144–53. PMID 12767050. doi:10.1002/jcp.10287.
Lin Z, Walther D, Yu XY, Drgon T, Uhl GR. . Pharmacogenetics. Dec 2004, 14 (12): 805–11. PMID 15608559. doi:10.1097/00008571-200412000-00003.

外部链接

. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2017-02-02）.
Human HTR2B genome location and HTR2B gene details page in the UCSC Genome Browser.

5-HT2B受體引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000135914 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000026228 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_3357-6] . （原始内容存档于2019-09-18）.

[pmid8143856-7] Schmuck K, Ullmer C, Engels P, Lübbert H. . FEBS Letters. Mar 1994, 342 (1): 85–90 [2017-01-24]. PMID 8143856. doi:10.1016/0014-5793(94)80590-3. （原始内容存档于2019-02-15）.